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In recent years, ABPP has been combined with mass-spectrometry-based platforms such as tandem MS and liquid chromatography MS (LC/MS) to achieve great coverage of the proteome [133–135]. A. Maxmen, “Beyond PARP inhibitors: agents in pipelines target DNA repair mechanisms,”, J. O'Shaughnessy et al., “Iniparib plus chemotherapy in metastatic triple-negative breast cancer,”, M. Green and G. Hortobagyi, “Chemotherapy for breast cancer,” in, R. Sankaranarayanan and J. Ferlay, “Worldwide burden of gynaecological cancer: the size of the problem,”, J. M. Walboomers, M. V. Jacobs, M. M. Manos et al., “Human papillomavirus is a necessary cause of invasive cervical cancer worldwide,”, H. zur Hausen, “Papillomaviruses and cancer: from basic studies to clinical application,”, E. K. Yim and J. S. Park, “Biomarkers in cervical cancer,”, D. Hu and S. Goldie, “The economic burden of noncervical human papillomavirus disease in the United States,”, P. Cattani, A. Siddu, S. D'Onghia et al., “RNA (E6 and E7) assays versus DNA (E6 and E7) assays for risk evaluation for women infected with human papillomavirus,”, J. Schweizer et al., “Feasibility study of a human papillomavirus E6 oncoprotein test for diagnosis of cervical precancer and cancer,”, R. Klaes, T. Friedrich, D. Spitkovsky et al., “Overexpression of p16(INK4A) as a specific marker for dysplastic and neoplastic epithelial cells of the cervix uteri,”, M. Dray, P. Russell, C. Dalrymple et al., “p16(INK4a) as a complementary marker of high-grade intraepithelial lesions of the uterine cervix. One reason outcomes are generally poor is that the majority of patients present with late-stage disease due to very general symptoms that may persist for years and could be attributed to other factors. Eun-Kyoung Yim Breuer, Mandi M. Murph, "The Role of Proteomics in the Diagnosis and Treatment of Women's Cancers: Current Trends in Technology and Future Opportunities", International Journal of Proteomics, vol. The Entrez search and retrieval system is a tool for accessing and searching a large range of databases, including protein databases and literature databases, such as PubMed. The diversity of the samples is further complicated by the fact that proteins have various isoforms and variants. Another disadvantage of using RPPA is that it requires very-high-quality antibodies that have been validated through traditional immunoblotting, which is a time-consuming bottleneck for this assay. Genetic and protein-sequence data are now available for many microorganisms and are providing tools for understanding their resistance to drugs and for identifying novel agents for treating drug-resistant disease.15,16 For example, azole resistance in Candida albicans has been linked with differential expression of proteins such as Erg10p, a protein involved in the ergosterol biosynthesis pathway.17 This is a potential drug target for the treatment of resistant disease. A serum screening test that could detect pre-clinical infection would allow early treatment, potentially reducing transmission, and have widespread application. This is because oestrogen is capable of driving the growth of oestrogen-dependent tumors, and inhibiting this hormonal factor is crucial to achieving a response to therapy. Sign up here as a reviewer to help fast-track new submissions. Wright and colleagues demonstrated the potential clinical use of ABPs in drug discovery for cancer-related enzymes. B. Heffron et al., “p16INK4A, CDC6, and MCM5: predictive biomarkers in cervical preinvasive neoplasia and cervical cancer,”, A. Freeman, L. S. Morris, A. D. Mills et al., “Minichromosome maintenance proteins as biological markers of dysplasia and malignancy,”, T. Brake, J. P. Connor, D. G. Petereit, and P. F. Lambert, “Comparative analysis of cervical cancer in women and in a human papillomavirus-transgenic mouse model: identification of minichromosome maintenance protein 7 as an informative biomarker for human cervical cancer,”, J. Hannemann, P. Kristel, H. Van Tinteren et al., “Molecular subtypes of breast cancer and amplification of topoisomerase IIalpha: predictive role in dose intensive adjuvant chemotherapy,”, Y. Chen, C. Miller, R. Mosher et al., “Identification of cervical cancer markers by cDNA and tissue microarrays,”, M. Branca et al., “Over-expression of topoisomerase IIalpha is related to the grade of cervical intraepithelial neoplasia (CIN) and high-risk human papillomavirus (HPV), but does not predict prognosis in cervical cancer or HPV clearance after cone treatment,”, A. P. Pinto et al., “Biomarker (ProEx C, p16(INK4A), and MiB-1) distinction of high-grade squamous intraepithelial lesion from its mimics,”, M. A. Fernandez, J. D. Allen, R. Mistry, and J. The Pap smear is the best example of a cancer screening program; however, sometimes false-positive or false-negative results do happen, leading to unnecessary followup or causing delay in the diagnosis and treatment of precancer and cancer, respectively. Thus, the high-throughput, novel, proteomic approach reverse phase protein array (RPPA) was developed to quantify signaling pathway activation using protein phosphorylation-specific antibodies among a large number of biological specimens, and RPPA was validated [140–142]. Advances in proteomics technology allow the simultaneous analysis of thousands of low molecular weight proteins, which may reveal patterns of disease and are potentially useful for early detection and assessing prognosis. The identification of a protein from its peptide sequence derived from the mass spectrum has been facilitated by the development of proteomics databases. Mass spectrometry offers a number of advantages for the biochemical analysis of lipids [84, 85], nucleic acid fragments, [86] and proteins, thus it has become a powerful and indispensable tool for proteomic studies [87–89]. Various automated image analysis software are currently available, and several groups have demonstrated that automated IHC scoring systems offer time efficiency, better accuracy, good reproducibility, and higher quality data compared to manual analysis [163–166]. Since the majority (approximately 75%) of ovarian cancer patients will relapse, some with refractory disease, the establishment of appropriate second-line therapy is critical. M Kavallaris is supported by a National Health and Medical Research Council RD Wright Career Development Award. The Role of Proteomics in the Diagnosis and Treatment of Women's Cancers: Current Trends in Technology and Future Opportunities, Department of Systems Biology, University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA, Department of Radiation Oncology, Loyola university of Chicago, Stritch School of Medicine, Maywood, IL 60153, USA, Department of Molecular Pharmacology and Therapeutics, Loyola university of Chicago, Stritch School of Medicine, Maywood, IL 60153, USA, Department of Pharmaceutical and Biomedical Sciences, College of Pharmacy, The University of Georgia, 240 W Green Street, Athens, GA 30602, USA.

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