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Questions? The lab confirmed that it was a member of the order Capnodiales, meaning it was a type of black sooty fungus. And although Kahn had left explicit instructions not to stain or paint the teak, it was clear that more than just bleach and water had been applied to some windows in attempts to arrest the creeping blackness. As a new chapter for the Salk begins, even the most astute architectural observer might have trouble placing a finger on exactly what has changed. “He realized the same people wouldn’t live in that house forever.”. Just convincing the caretaker of a 50-year-old building that modern architecture needs to be conserved can be difficult, says Susan Macdonald, head of field projects for the CGI. They sat in the University of Pennsylvania’s library with fellow Kahn stewards, poring over the original plans for their houses and listening to lectures from famous wood scientists.
Kahn only used exterior teak in one other location, the Phillips Exeter Library in New Hampshire, where it was subjected to frost and freeze—and no eucalyptus trees—which have aged the wood in a radically different way.

This field is for validation purposes and should be left unchanged. The results revealed that metformin turns on unexpected kinases and pathways, many independent of AMPK. This NIH requirement must be satisfied as part of our efforts to provide consistent access to stabling funded core resources. Outside of lab, he likes to travel, explore new places and loves following sports in general (mainly soccer!). Previously, the only biochemical pathway that was known to be activated by metformin was the AMPK pathway, which Shaw discovered stalls cell growth and changes metabolism when nutrients are scarce, as can occur in cancer.
In fact, the Esherick House has the same style of wooden window walls as the Salk. It’s difficult to know exactly what shade he meant to achieve using teak. Jolene Diedrich, PhD Associate Director jdiedrich@salk.edu. Mass Spectrometry Specialist. In many ways, the building has been easy to manage because it was so ahead of its time when it opened in 1963, says Tim Ball, senior facilities director at the Salk since 2008 and the building’s passionate steward. Fifty years later, it was clear that this strategy was not sustainable—and the problem was getting worse. The Thermo Orbitrap Fusion mass spectrometer combines its three mass analyzers -quadrupole, Orbitrap and linear ion trap in a Tribrid architecture that provides unprecedented depth of analysis for complex biological samples. Home - Science - Core Facilities - Mass Spectrometry Core - Scheduling & Rates. This job fell to Kyle Normandin, associate principal at Wiss, Janney, Elstner Associates, Inc., the firm that served as architect of record for the restoration process.

This field is for validation purposes and should be left unchanged. Just after the installation last winter, Southern California was treated to a series of particularly intense storms. We’ve done it in a way that’s non-intrusive.”. In healthy cells and tissues, it is these proteins and metabolites that keep biological processes functioning properly. With scientists eager to move into their labs, some details of the design, like Kahn’s recommendation to add window flashings, were never implemented, leaving Ball’s team to contend with decades of leaks and water damage. "Being mentored by John Yates, one of the top mass spectrometry investigators in the world, and Reuben Shaw, an expert in the field of metabolism, enabled me to both develop and apply a novel technology to a critical biological question: What pathways are regulated by metformin in the liver?"

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